Showing posts with label evolution. Show all posts
Showing posts with label evolution. Show all posts

Sunday, September 14, 2008

Prebiotic Synthesis


Since taking Evolution (BIO 460) during the spring quarter, I have become especially interested in the field of prebiotic synthesis - the field that tries to find what biochemical reactions preceded the earliest life forms (and thus further proving to Sarah Palin and gang that we didn't just show up 6000 years ago). In an article published in Science, Barta argues that the reaction barrier to a condensation reaction to link amino acids as opposed to a acid-base reaction (since AA's are amphoteric in nature). The mechanism of the reaction is pretty interesting, check it out!

Wednesday, July 2, 2008

Evolution is lazy and doesn't care about the old

Having read a few books about evolution recently, it certainly seems like evolution is a bit lazy. Random mutation creates traits that may or may not be beneficial to the organism in the short run. The ones that are selected for are those that are beneficial in the short term (technically, those that improve reproductive fitness). Traits that help an organism in the short term (before reproductive maturity) and help an organism to survive till that point are selected for - even those that are detrimental down the line. Many genetic disorders such as (I can't remember - it's one of those that are commonly referred to in genetics books... Huntington's?) are adult-onset, usually during mid-life, after one has kids. Thus this disease is not selected for and the person survives to pass on the disease DNA. There has been research into whether these disease provide some moderate level of benefit to the organism, or whether they are just "piggyback diseases", similar to piggyback bills in Congress that just happen to make it through because they don't really matter and are passed along with another, more prominent one. IF this is the case, evolution is lazy - it conferred that particular benefit without regard for its detimental effects, or in another way of thinking about it, it was the "easiest" way to confer the benefit (by completely ignoring the massive downside). Of course, that's not true, but it's an amusing and cynical way of thinking about. In the same way it doesn't care about geriatrics - there is essentially no pressure against disease that appear late in life.

I have long thought about how humans have thwarted evolution in many senses - we don't necessarily mate according to fitness. The people who have kids are in no way representative of the most fit genetically, but rather that they just best followed the memes of society or socially matched up with someone enough to reproduce. We're living to ages way beyond our bodies were prepared for, and unlike any other species, mental fitness matters immensely over physical fitness. Of course, professional athletes do pretty well for themselves, but otherwise, as a species, we survive because of our minds. Our scientific/medical knowledge has brought up our whole society rather than preserving only the individuals who happen to have that knowledge, as would a beneficial physical trait.

For example, imagine a dinosaur that grows extra long and sharp claws because of some mutation in the claw-growth-stopping-gene. It's hard to imagine that trait would help all of that dinosaur's species. On the other hand, if I come up with a vaccine for HIV next week, it would help our whole species, diminishing the fitness-spread between me (the one with the trait that actually made the vaccine) and the rest of the population. Not that we shouldn't cooperate of course. Just musing.

Monday, June 2, 2008

The First Protein


Which of the well known critical cell proteins would have formed first and started a cascade that would lead to life? I'm not too well read on prebiotic synthesis and other such matters, but it seems to me that it would have been very beneficial for DNA polymerase to be created at the very least. Thus at least some DNA would be replicated, which seems to be the very minimum for life, right? At the same time to make most proteins you need some sort of a ribosome as it is difficult to carry out the reaction needed to polymerize amino acids in a normal environment. This is the function of one of the units of the ribosome (forget whether it is the 70 or 30S). Anyway, just a musing - any thoughts?

Tuesday, May 27, 2008

UPenn Archeology and Anthropology Museum


Today I visited the UPenn Museum of Archeology and Anthropology, primarily for the new "Surviving" exhibit. It goes into evolution, specifically human evolution, and how many of our current traits have ancestral (plesiomorphic) origins. However, I believe that the phrasing of the explanations in the exhibit is dangerous, because it indicates a erroneous cause-and-effect relationship in order to make it easy to understand. Whereas Darwin indicated that random changes in the population are selected for, which leads to the persistence of beneficial adaptations, the exhibit tended to explain that the reason we have certain characteristics is for a purpose. This is dangerously close to Intelligent Design, even though the exhibit's authors clearly believe in ancient, non-creationist origins. What we should be inculcating in today's youth and in all of society in general is that natural selection is the main mechanism of evolution and how this occurs, as this is what makes evolution the most clear. While it is certainly amazing that we are what we are and that our bodies are amazingly intricate, such phraseology leads to incorrect understanding.

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